Allergy360
Allergy360 is our comprehensive allergy test, measuring immune response to allergens with treatment monitoring markers
Allergy360 detects up to four biomarkers for each allergen to determine hypersensitivities and other inflammatory responses.
More than 50 million Americans suffer from chronic allergies
Allergy360 Panels
Allergy360 detects up to four biomarkers for each allergen to determine hypersensitivities and other inflammatory responses.
Food Allergies
Allergy Dietary panels detect IgE allergic reactivity and sensitivities. It also monitors the immune reactivity of IgG4 that competes with IgE for binding sites on specific allergen(s). IgE usually occurs immediately and can create severe symptoms such as swelling, hives, itching, and in worst cases – anaphylaxis.
Environmental Allergies
Allergy360 Environmental panels detect IgE reactivity to environmental allergens that are inhaled or contacted. The higher the value the greater the potential risk of an allergic reaction. It also detects the immune reactivity from exposure to allergens and how IgG4 competes with IgE for binding sites on specific allergens. The detection of these exposures can be used to establish baselines of hypersensitivity to specific allergen(s) as well as be used as a tool to manage the clinical efficacy of immunotherapy for the neutralization of offending IgE species.
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Food allergy is a problem of epidemic proportions, with 60% of Americans suffering from unsuspected food reactions.
- About 32 million Americans have food allergies
- Every three minutes a food allergy reaction sends someone to the emergency room
- Each year 200,000 Americans require emergency medical care for allergic reactions to food
- Every year food allergies cost about $25 billion in treatment and loss in productivity
Better Information for Confident Decisions
We deliver fast and accurate results with unique information and insights to better match the right patient to the right treatment.
IgE
The IgE antibody response is the most commonly known allergen response. IgE reactions stimulate the release of histamine in the body. The results of IgE may indicate if a patient has a Type I hypersensitivity (or immediate hypersensitivity) which is an allergic reaction provoked by exposure to an allergen (environmental or food). The presence of allergy related symptoms confirms IgE allergy.
IgG4 and Blocking Potential
IgG4 is a subclass of IgG and comprises only 4% of IgG antibodies. IgG4 serves as an indicator of the extent of allergen exposure and are produced after long-term exposure to an antigen. IgG4 total antibody is important in relation to IgE because this antibody acts as a blocking agent for an IgE reaction. When the IgG4 reaction is greater than the IgE reaction for a particular antigen, IgG4 may block the IgE antibodies from binding to the receptor sites and releasing histamine, thereby reducing the severity of the symptoms associated with the IgE reaction. This is referred to as the Blocking Potential. Higher IgG4 improves the odds of neutralization IgE reactivity and prevents allergen specific adverse reactions from occurring. The blocking potential value to specific allergens must be used in conjunction with the patient’s symptoms. Furthermore, IgG4 may also be used to manage the clinical efficacy of immunotherapy for the neutralization of IgE reactions. 3 IgG4 antibodies not only block IgE mediated allergies but also block the reactions of other IgG subclasses, reducing inflammatory reactions caused by other IgG subclasses.
C3D
C3D is a complement antigen and an activator of our complement cascade system. Reaction to the specified food will worsen if C3D activation is present. 10 The C3 protein attaches to the antigen and amplifies the IgG response, increasing the inflammatory potential of IgG titer. The results of C3D may determine Type III hypersensitivity when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response.
IgG
IgG immune complexes can be deposited in tissues, leading to inflammation. IgG1, IgG2, and IgG3 all are capable of causing inflammation because they activate complement, resulting in an inflammatory cascade that is associated with IBS, IBD, eczema, migraines, autism, anxiety, depression, and obesity. However, there’s a fourth IgG subclass – IgG4 – that does not bind to complement and therefore does not trigger inflammation. Confusion about dietary allergy and dietary intolerance or inflammation can cause misinterpretation. A IgG reaction is different than an immediately life-threatening food allergy (IgE). IgG is the most abundant circulating antibody in our immune system, can cause a delayed immune reaction and they are never life threatening.
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Allergy360 gives you the critical insights to provide incredible care. Contact us today to order testing.